报告人: Prof. Chaoyang (Joe) Zhang
Director of the School of Computing at the University of Southern Mississippi
报告时间：6月14日 星期五 上午10:00
报告地点：浙江大学 CSC223会议室

报告摘要:
The novel molecular biological technology, microarray, makes it feasible to obtain quantitative measurements of expression of thousands of genes present in a biological sample simultaneously. Genome-wide expression data generated from this technology are promising to uncover the implicit and previously unknown biological knowledge. In this presentation, I will introduce several microarray data mining techniques including feature selection, classifier genes identification and generation of reference genetic interaction network for non-model organisms, and also introduce a new Bayesian learning and optimization approach (BLOM) developed in our Computational Biology and Bioinformatics Laboratory for inferring gene regulatory networks from time series data. After extensive testing and validation using both synthetic and yeast cell cycle benchmark datasets, the BLOM was used to study toxicity of chemicals using earthworm and E. coli live cell time series datasets. The proposed approach successfully identified hub genes and several important gene regulation relationships in the pathways and also addressed the dynamic change of biological networks in the course of the treatment and recovery.

报告人简介:

Dr. Chaoyang (Joe) Zhang received his Master Degree in Computer Science and Ph.D. in Computational Analysis and Modeling from the Louisiana Tech University in 2001.Now he is the Director and Professor in the School of Computing at the University of Southern Mississippi. Dr. Zhang built the Computational Biology and Bioinformatics Lab at Southern Miss in 2007. He has been the PI or CO-PI of sixteen external grants with approximately four million dollars, supported by USA National Science Foundation, National Institute of Health, Department of Defense and Department of Homeland Security.Dr. Zhang has more than sixty peer-reviewed publications. He won the Sylvia SorkinGreenfiled Award for the best paper published in Medical Physics journal in 2004. His PhD student and he won the second place of the DREAM Challenge competition among more than 30 international teams, which was organized by Columbia University and IBM in 2008. Dr. Zhangwas a Co-Founder and Program Committee Chair of the 2009 International Joint Conferences on Bioinformatics, System Biology and Intelligent Computing (IJCBS 09) and the Steering Committee Co-Chair of The ACM 2010 International Conference on Bioinformatics and Computing Biology (ACM-BCB 2010). He helped found the ACM Special Interest Group �C SIGBioinformatics in 2010 and served as the Award Co-Chair. He was selected to serve as the 2014-2015 President of the Midsouth Computational Biology and Bioinformatics Society. He is also an associate editor of the American Journal of Science and Engineering.